STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease

Emerging evidence suggests that innate immunity drives alcoholic liver disease (ALD) and that the interferon regulatory factor 3 (IRF3),a transcription factor regulating innate immune responses, is indispensable for the development of ALD. Here we report that IRF3 mediates ALD via linking endoplasmi...

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Detalhes bibliográficos
Main Authors: Petrasek, Jan, Iracheta-Vellve, Arvin, Csak, Timea, Satishchandran, Abhishek, Kodys, Karen, Kurt-Jones, Evelyn A., Fitzgerald, Katherine A., Szabo, Gyongyi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799324/
https://ncbi.nlm.nih.gov/pubmed/24052526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1308331110
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