STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease

Emerging evidence suggests that innate immunity drives alcoholic liver disease (ALD) and that the interferon regulatory factor 3 (IRF3),a transcription factor regulating innate immune responses, is indispensable for the development of ALD. Here we report that IRF3 mediates ALD via linking endoplasmi...

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Главные авторы: Petrasek, Jan, Iracheta-Vellve, Arvin, Csak, Timea, Satishchandran, Abhishek, Kodys, Karen, Kurt-Jones, Evelyn A., Fitzgerald, Katherine A., Szabo, Gyongyi
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2013
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799324/
https://ncbi.nlm.nih.gov/pubmed/24052526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1308331110
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