STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease

Emerging evidence suggests that innate immunity drives alcoholic liver disease (ALD) and that the interferon regulatory factor 3 (IRF3),a transcription factor regulating innate immune responses, is indispensable for the development of ALD. Here we report that IRF3 mediates ALD via linking endoplasmi...

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Bibliografische gegevens
Hoofdauteurs: Petrasek, Jan, Iracheta-Vellve, Arvin, Csak, Timea, Satishchandran, Abhishek, Kodys, Karen, Kurt-Jones, Evelyn A., Fitzgerald, Katherine A., Szabo, Gyongyi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2013
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799324/
https://ncbi.nlm.nih.gov/pubmed/24052526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1308331110
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