STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease

Emerging evidence suggests that innate immunity drives alcoholic liver disease (ALD) and that the interferon regulatory factor 3 (IRF3),a transcription factor regulating innate immune responses, is indispensable for the development of ALD. Here we report that IRF3 mediates ALD via linking endoplasmi...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Petrasek, Jan, Iracheta-Vellve, Arvin, Csak, Timea, Satishchandran, Abhishek, Kodys, Karen, Kurt-Jones, Evelyn A., Fitzgerald, Katherine A., Szabo, Gyongyi
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2013
विषय:
Biological Sciences
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799324/
https://ncbi.nlm.nih.gov/pubmed/24052526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1308331110
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