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Immunosenescence is associated with altered gene expression and epigenetic regulation in primary and secondary immune organs

Deterioration of the immune system (immunosenescence) with age is associated with an increased susceptibility to infection, autoimmune disease and cancer, and reduced responsiveness to vaccination. Immunosenescence entails a reduced supply of naïve T cells from the thymus and increased specializatio...

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Autors principals: Sidler, Corinne, Wóycicki, Rafał, Ilnytskyy, Yaroslav, Metz, Gerlinde, Kovalchuk, Igor, Kovalchuk, Olga
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798808/
https://ncbi.nlm.nih.gov/pubmed/24151501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2013.00211
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