Examination of Matrix Metalloproteinase-1 in Solution: A PREFERENCE FOR THE PRE-COLLAGENOLYSIS STATE

Catalysis of collagen degradation by matrix metalloproteinase 1 (MMP-1) has been proposed to critically rely on flexibility between the catalytic (CAT) and hemopexin-like (HPX) domains. A rigorous assessment of the most readily accessed conformations in solution is required to explain the onset of s...

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Detalhes bibliográficos
Main Authors: Cerofolini, Linda, Fields, Gregg B., Fragai, Marco, Geraldes, Carlos F. G. C., Luchinat, Claudio, Parigi, Giacomo, Ravera, Enrico, Svergun, Dmitri I., Teixeira, João M. C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798536/
https://ncbi.nlm.nih.gov/pubmed/24025334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.477240
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