Sculpting MHC class II-restricted self and non-self peptidome by the class I antigen-processing machinery and its impact on CD4(+) TCR repertoire and Th cell responses

It is generally assumed that the MHC class I antigen (Ag)-processing (CAP) machinery —which supplies peptides for presentation by class I molecules— plays no role in class II-restricted presentation of cytoplasmic Ags. In striking contrast to this assumption, we previously reported that proteasome i...

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Hlavní autoři: Spencer, Charles T., Dragovic, Srdjan M., Conant, Stephanie B., Gray, Jennifer J., Zheng, Mu, Samir, Parimal, Niu, Xinnan, Moutaftsi, Magdalini, Van Kaer, Luc, Sette, Alessandro, Link, Andrew J., Joyce, Sebastian
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798073/
https://ncbi.nlm.nih.gov/pubmed/23386199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201243087
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