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Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness
Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid. Phosphatidic acid participates in both G protein-coupled receptor and receptor tyrosine kinase signal transduction networks. The lack of potent and isoform-selective inhibitor...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3798018/ https://ncbi.nlm.nih.gov/pubmed/19136975 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.140 |
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