Targeted Gene Deletion of miRNAs in Mice by TALEN System

Mice are among the most valuable model animal species with an enormous amount of heritage in genetic modification studies. However, targeting genes in mice is sometimes difficult, especially for small genes, such as microRNAs (miRNAs) and targeting genes in repeat sequences. Here we optimized the ap...

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Bibliographic Details
Main Authors: Takada, Shuji, Sato, Tempei, Ito, Yoshiaki, Yamashita, Satoshi, Kato, Tomoko, Kawasumi, Miyuri, Kanai-Azuma, Masami, Igarashi, Arisa, Kato, Tomomi, Tamano, Moe, Asahara, Hiroshi
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3797721/
https://ncbi.nlm.nih.gov/pubmed/24146809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0076004
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