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Phosphorylated Phospholamban Stabilizes a Compact Conformation of the Cardiac Calcium-ATPase

The sarcoendoplasmic reticulum calcium ATPase (SERCA) plays a key role in cardiac calcium handling and is considered a high-value target for the treatment of heart failure. SERCA undergoes conformational changes as it harnesses the chemical energy of ATP for active transport. X-ray crystallography h...

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Detalhes bibliográficos
Main Authors: Pallikkuth, Sandeep, Blackwell, Daniel J., Hu, Zhihong, Hou, Zhanjia, Zieman, Dane T., Svensson, Bengt, Thomas, David D., Robia, Seth L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3797577/
https://ncbi.nlm.nih.gov/pubmed/24138857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.08.045
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