Chargement en cours...
Lethal Arg9Cys phospholamban mutation hinders Ca(2+)-ATPase regulation and phosphorylation by protein kinase A
The regulatory interaction of phospholamban (PLN) with Ca(2+)-ATPase controls the uptake of calcium into the sarcoplasmic reticulum, modulating heart muscle contractility. A missense mutation in PLN cytoplasmic domain (R9C) triggers dilated cardiomyopathy in humans, leading to premature death. Using...
Enregistré dans:
| Auteurs principaux: | , , , , , , |
|---|---|
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2011
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3041113/ https://ncbi.nlm.nih.gov/pubmed/21282613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1013987108 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|