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Lethal Arg9Cys phospholamban mutation hinders Ca(2+)-ATPase regulation and phosphorylation by protein kinase A
The regulatory interaction of phospholamban (PLN) with Ca(2+)-ATPase controls the uptake of calcium into the sarcoplasmic reticulum, modulating heart muscle contractility. A missense mutation in PLN cytoplasmic domain (R9C) triggers dilated cardiomyopathy in humans, leading to premature death. Using...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3041113/ https://ncbi.nlm.nih.gov/pubmed/21282613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1013987108 |
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