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Phosphomimetic Mutations Increase Phospholamban Oligomerization and Alter the Structure of Its Regulatory Complex

To investigate the effect of phosphorylation on the interactions of phospholamban (PLB) with itself and its regulatory target, SERCA, we measured FRET from CFP-SERCA or CFP-PLB to YFP-PLB in live AAV-293 cells. Phosphorylation of PLB was mimicked by mutations S16E (PKA site) or S16E/T17E (PKA+CaMKII...

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書誌詳細
主要な著者: Hou, Zhanjia, Kelly, Eileen M., Robia, Seth L.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570860/
https://ncbi.nlm.nih.gov/pubmed/18708665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804782200
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