A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization

Germline mis-sense mutations affecting a single BRCA2 allele predispose humans to cancer. Here, we identify a protein-targeting mechanism disrupted by the cancer-associated mutation, BRCA2(D2723H) that controls the nuclear localization of BRCA2 and its cargo, the recombination enzyme RAD51. A nuclea...

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Hlavní autoři: Jeyasekharan, Anand D, Liu, Yang, Hattori, Hiroyoshi, Pisupati, Venkat, Jonsdottir, Asta Bjork, Rajendra, Eeson, Lee, Miyoung, Sundaramoorthy, Elayanambi, Schlachter, Simon, Kaminski, Clemens, Ofir-Rosenfeld, Yaara, Sato, Ko, Savill, Jane, Ayoub, Nabieh, Venkitaraman, Ashok R
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3796201/
https://ncbi.nlm.nih.gov/pubmed/24013206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2666
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