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DNA damage regulates the mobility of Brca2 within the nucleoplasm of living cells
How the biochemical reactions that lead to the repair of DNA damage are controlled by the diffusion and availability of protein reactants within the nucleoplasm is poorly understood. Here, we use gene targeting to replace Brca2 (a cancer suppressor protein essential for DNA repair) with a functional...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3003017/ https://ncbi.nlm.nih.gov/pubmed/21098284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009577107 |
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