DNA damage regulates the mobility of Brca2 within the nucleoplasm of living cells

How the biochemical reactions that lead to the repair of DNA damage are controlled by the diffusion and availability of protein reactants within the nucleoplasm is poorly understood. Here, we use gene targeting to replace Brca2 (a cancer suppressor protein essential for DNA repair) with a functional...

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Bibliographic Details
Main Authors: Jeyasekharan, Anand D., Ayoub, Nabieh, Mahen, Robert, Ries, Jonas, Esposito, Alessandro, Rajendra, Eeson, Hattori, Hiroyoshi, Kulkarni, Rajan P., Venkitaraman, Ashok R.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2010
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003017/
https://ncbi.nlm.nih.gov/pubmed/21098284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009577107
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