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Crystal structure of a complex of human chymase with its benzimidazole derived inhibitor
The crystal structure of human chymase complexed with a novel benzimidazole inhibitor, TJK002, was determined at 2.8 Å resolution. The X-ray crystallographic study shows that the benzimidazole inhibitor forms a non-covalent interaction with the catalytic domain of human chymase. The hydrophobic frag...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
International Union of Crystallography
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3795555/ https://ncbi.nlm.nih.gov/pubmed/24121339 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0909049513020748 |
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