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Crystal structure of a complex of human chymase with its benzimidazole derived inhibitor

The crystal structure of human chymase complexed with a novel benzimidazole inhibitor, TJK002, was determined at 2.8 Å resolution. The X-ray crystallographic study shows that the benzimidazole inhibitor forms a non-covalent interaction with the catalytic domain of human chymase. The hydrophobic frag...

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מידע ביבליוגרפי
Main Authors: Matsumoto, Yoshiyuki, Kakuda, Shinji, Koizumi, Masahiro, Mizuno, Tsuyoshi, Muroga, Yumiko, Kawamura, Takashi, Takimoto-Kamimura, Midori
פורמט: Artigo
שפה:Inglês
יצא לאור: International Union of Crystallography 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795555/
https://ncbi.nlm.nih.gov/pubmed/24121339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0909049513020748
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