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Crystal structure of human cyclin-dependent kinase-2 complex with MK2 inhibitor TEI-I01800: insight into the selectivity

Mitogen-activated protein kinase-activated protein kinase 2 (MK2 or MAPKAP-K2) is a Ser/Thr kinase from the p38 mitogen-activated protein kinase signalling pathway and plays an important role in inflammatory diseases. The crystal structure of the MK2–TEI-I01800 complex has been reported; its Gly-ric...

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Autors principals: Fujino, Aiko, Fukushima, Kei, Kubota, Takaharu, Kosugi, Tomomi, Takimoto-Kamimura, Midori
Format: Artigo
Idioma:Inglês
Publicat: International Union of Crystallography 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795553/
https://ncbi.nlm.nih.gov/pubmed/24121337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0909049513020736
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