Implications for immunotherapy of tumor-mediated T-cell apoptosis associated with loss of the tumor suppressor PTEN in glioblastoma

The ability of glioma cells to escape the immune system remains a significant barrier to successful immunotherapy. Here we demonstrate that loss of the PTEN tumor suppressor gene, with associated activation of the PI3K/Akt/mTOR pathway, leads to a human glioma phenotype that induces autologous T-cel...

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Hlavní autoři: Waldron, James S., Yang, Isaac, Han, Seunggu, Tihan, Tarik, Sughrue, Michael E., Mills, Steven A., Pieper, Russell O., Parsa, Andrew T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795509/
https://ncbi.nlm.nih.gov/pubmed/20822910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jocn.2010.04.021
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