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PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma
The PI3K-Akt pathway is activated in cancer by genetic or epigenetic events and efforts are under way to develop targeted therapies. PTEN tumor suppressor is the major brake of the pathway and a common target for inactivation in glioblastoma, one of the most aggressive and therapy-resistant cancers....
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3208076/ https://ncbi.nlm.nih.gov/pubmed/21804599 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.324 |
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