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PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma

The PI3K-Akt pathway is activated in cancer by genetic or epigenetic events and efforts are under way to develop targeted therapies. PTEN tumor suppressor is the major brake of the pathway and a common target for inactivation in glioblastoma, one of the most aggressive and therapy-resistant cancers....

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Bibliografiske detaljer
Main Authors: Molina, Jennifer R., Agarwal, Nitin K., Morales, Fabiana C., Hayashi, Yuho, Aldape, Kenneth D., Cote, Gilbert, Georgescu, Maria-Magdalena
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208076/
https://ncbi.nlm.nih.gov/pubmed/21804599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.324
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