Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKβ

Notch signaling is frequently hyperactivated in breast cancer, but how the enhanced signaling contributes to the tumor process is less well understood. In this report, we identify the proinflammatory cytokine interleukin-6 (IL-6) as a novel Notch target in breast tumor cells. Enhanced Notch signalin...

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Bibliographische Detailangaben
Hauptverfasser: Jin, S, Mutvei, A P, Chivukula, I V, Andersson, E R, Ramsköld, D, Sandberg, R, Lee, K L, Kronqvist, P, Mamaeva, V, Östling, P, Mpindi, J-P, Kallioniemi, O, Screpanti, I, Poellinger, L, Sahlgren, C, Lendahl, U
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2013
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795477/
https://ncbi.nlm.nih.gov/pubmed/23178494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.517
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