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Role of antigen-specific regulatory CD4(+)CD25(+) T cells in tolerance induction after neonatal IP administration of AAV-hF.IX
Neonatal AAV8-mediated Factor IX (F.IX) gene delivery was applied as a model for exploring mechanisms of tolerance induction during immune ontogeny. Intraperitoneal delivery of AAV8/ Factor IX (hF.IX) during weeks 1–4 of life, over a 20-fold dose range, directed stable hF.IX expression, correction o...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3795474/ https://ncbi.nlm.nih.gov/pubmed/23759700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2013.22 |
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