Role of antigen-specific regulatory CD4(+)CD25(+) T cells in tolerance induction after neonatal IP administration of AAV-hF.IX

Neonatal AAV8-mediated Factor IX (F.IX) gene delivery was applied as a model for exploring mechanisms of tolerance induction during immune ontogeny. Intraperitoneal delivery of AAV8/ Factor IX (hF.IX) during weeks 1–4 of life, over a 20-fold dose range, directed stable hF.IX expression, correction o...

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Detalhes bibliográficos
Main Authors: Shi, Y, Falahati, R, Zhang, J, Flebbe-Rehwaldt, L, Gaensler, K M L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795474/
https://ncbi.nlm.nih.gov/pubmed/23759700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2013.22
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