A Mathematical Model for Scanning and Catalysis on Single-stranded DNA, Illustrated with Activation-induced Deoxycytidine Deaminase

We formulated a master equation-based mathematical model to analyze random scanning and catalysis for enzymes that act on single-stranded DNA (ssDNA) substrates. Catalytic efficiencies and intrinsic scanning distances are deduced from the distribution of positions and gap lengths between a series of...

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Autors principals: Mak, Chi H., Pham, Phuong, Afif, Samir A., Goodman, Myron F.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Enzymology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795277/
https://ncbi.nlm.nih.gov/pubmed/23979486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.506550
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