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Ubiquitin E3 Ligase CRL4(CDT2/DCAF2) as a Potential Chemotherapeutic Target for Ovarian Surface Epithelial Cancer
Cullin-RING ubiquitin ligases (CRLs) are the largest family of E3 ligases and require cullin neddylation for their activation. The NEDD8-activating enzyme inhibitor MLN4924 reportedly blocked cullin neddylation and inactivated CRLs, which resulted in apoptosis induction and tumor suppression. Howeve...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3795265/ https://ncbi.nlm.nih.gov/pubmed/23995842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.495069 |
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