Ubiquitin E3 Ligase CRL4(CDT2/DCAF2) as a Potential Chemotherapeutic Target for Ovarian Surface Epithelial Cancer

Cullin-RING ubiquitin ligases (CRLs) are the largest family of E3 ligases and require cullin neddylation for their activation. The NEDD8-activating enzyme inhibitor MLN4924 reportedly blocked cullin neddylation and inactivated CRLs, which resulted in apoptosis induction and tumor suppression. Howeve...

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Hlavní autoři: Pan, Wei-Wei, Zhou, Jian-Jie, Yu, Chao, Xu, Ying, Guo, Lian-Jun, Zhang, Hai-Yi, Zhou, Dawang, Song, Fang-Zhou, Fan, Heng-Yu
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795265/
https://ncbi.nlm.nih.gov/pubmed/23995842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.495069
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