A Novel Function of CRL4(Cdt2): REGULATION OF THE SUBUNIT STRUCTURE OF DNA POLYMERASE δ IN RESPONSE TO DNA DAMAGE AND DURING THE S PHASE

DNA polymerase δ (Pol δ4) is a heterotetrameric enzyme, whose p12 subunit is degraded in response to DNA damage, leaving behind a trimer (Pol δ3) with altered enzymatic characteristics that participate in gap filling during DNA repair. We demonstrate that CRL4(Cdt2), a key regulator of cell cycle pr...

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Detalhes bibliográficos
Main Authors: Zhang, Sufang, Zhao, Hong, Darzynkiewicz, Zbiegniew, Zhou, Pengbo, Zhang, Zhongtao, Lee, Ernest Y. C., Lee, Marietta Y. W. T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795253/
https://ncbi.nlm.nih.gov/pubmed/23913683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.490466
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