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Zn(2+) Mediates High Affinity Binding of Heparin to the αC Domain of Fibrinogen
The nonspecific binding of heparin to plasma proteins compromises its anticoagulant activity by reducing the amount of heparin available to bind antithrombin. In addition, interaction of heparin with fibrin promotes formation of a ternary heparin-thrombin-fibrin complex that protects fibrin-bound th...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3795240/ https://ncbi.nlm.nih.gov/pubmed/23990470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.469916 |
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