The Housekeeping Gene Hypoxanthine Guanine Phosphoribosyltransferase (HPRT) Regulates Multiple Developmental and Metabolic Pathways of Murine Embryonic Stem Cell Neuronal Differentiation

The mechanisms by which mutations of the purinergic housekeeping gene hypoxanthine guanine phosphoribosyltransferase (HPRT) cause the severe neurodevelopmental Lesch Nyhan Disease (LND) are poorly understood. The best recognized neural consequences of HPRT deficiency are defective basal ganglia expr...

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Bibliographische Detailangaben
Hauptverfasser: Kang, Tae Hyuk, Park, Yongjin, Bader, Joel S., Friedmann, Theodore
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3794013/
https://ncbi.nlm.nih.gov/pubmed/24130677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074967
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