Deficiency of the Housekeeping Gene Hypoxanthine–Guanine Phosphoribosyltransferase (HPRT) Dysregulates Neurogenesis

Neuronal transcription factors play vital roles in the specification and development of neurons, including dopaminergic (DA) neurons. Mutations in the gene encoding the purine biosynthetic enzyme hypoxanthine–guanine phosphoribosyltransferase (HPRT) cause the resulting intractable and largely untrea...

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Hlavní autoři: Guibinga, Ghiabe-Henri, Hsu, Stephen, Friedmann, Theodore
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2009
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2839227/
https://ncbi.nlm.nih.gov/pubmed/19672249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.178
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