The Housekeeping Gene Hypoxanthine Guanine Phosphoribosyltransferase (HPRT) Regulates Multiple Developmental and Metabolic Pathways of Murine Embryonic Stem Cell Neuronal Differentiation

The mechanisms by which mutations of the purinergic housekeeping gene hypoxanthine guanine phosphoribosyltransferase (HPRT) cause the severe neurodevelopmental Lesch Nyhan Disease (LND) are poorly understood. The best recognized neural consequences of HPRT deficiency are defective basal ganglia expr...

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Autori principali: Kang, Tae Hyuk, Park, Yongjin, Bader, Joel S., Friedmann, Theodore
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3794013/
https://ncbi.nlm.nih.gov/pubmed/24130677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074967
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