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Deficiency of the Housekeeping Gene Hypoxanthine–Guanine Phosphoribosyltransferase (HPRT) Dysregulates Neurogenesis

Neuronal transcription factors play vital roles in the specification and development of neurons, including dopaminergic (DA) neurons. Mutations in the gene encoding the purine biosynthetic enzyme hypoxanthine–guanine phosphoribosyltransferase (HPRT) cause the resulting intractable and largely untrea...

詳細記述

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書誌詳細
主要な著者: Guibinga, Ghiabe-Henri, Hsu, Stephen, Friedmann, Theodore
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2839227/
https://ncbi.nlm.nih.gov/pubmed/19672249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.178
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