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Regulation of Chk1 Kinase by Autoinhibition and ATR-mediated Phosphorylation
The checkpoint kinase Chk1 undergoes ATR-mediated phosphorylation and activation in response to unreplicated DNA, but the precise mechanism of Chk1 activation is not known. In this study, we have analyzed the domain structure of Xenopus Chk1 and explored the mechanism of its activation by ATR-mediat...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The American Society for Cell Biology
2004
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC379266/ https://ncbi.nlm.nih.gov/pubmed/14767054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E03-12-0874 |
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