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Structures of oncogenic, suppressor and rescued p53 core-domain variants: mechanisms of mutant p53 rescue
To gain insights into the mechanisms by which certain second-site suppressor mutations rescue the function of a significant number of cancer mutations of the tumor suppressor protein p53, X-ray crystallographic structures of four p53 core-domain variants were determined. These include an oncogenic m...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
International Union of Crystallography
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3792646/ https://ncbi.nlm.nih.gov/pubmed/24100332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444913020830 |
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