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Dissection of the Dislocation Pathway for Type I Membrane Proteins with a New Small Molecule Inhibitor, Eeyarestatin

The mammalian endoplasmic reticulum (ER)-to-cytosol degradation pathway for disposal of misfolded proteins is an attractive target for therapeutic intervention in diseases that are characterized by impaired protein degradation. The ability to do so is hampered by the small number of specific inhibit...

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Udgivet i:Mol Biol Cell
Principais autores: Fiebiger, Edda, Hirsch, Christian, Vyas, Jatin M., Gordon, Eva, Ploegh, Hidde L., Tortorella, Domenico
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Cell Biology 2004
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Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC379262/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14767067/
https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.E03-07-0506
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