Dissection of the Dislocation Pathway for Type I Membrane Proteins with a New Small Molecule Inhibitor, Eeyarestatin

The mammalian endoplasmic reticulum (ER)-to-cytosol degradation pathway for disposal of misfolded proteins is an attractive target for therapeutic intervention in diseases that are characterized by impaired protein degradation. The ability to do so is hampered by the small number of specific inhibit...

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Veröffentlicht in:	Mol Biol Cell
Hauptverfasser:	Fiebiger, Edda, Hirsch, Christian, Vyas, Jatin M., Gordon, Eva, Ploegh, Hidde L., Tortorella, Domenico
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Cell Biology 2004
Schlagworte:	Articles
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC379262/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14767067/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.E03-07-0506
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