Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization

Broadly neutralizing antibodies to HIV-1 (bNAbs) can prevent infection and are therefore of great importance for HIV-1 vaccine design. Notably, bNAbs are highly somatically mutated and generated by a fraction of HIV-1-infected individuals several years after infection. Antibodies typically accumulat...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Klein, Florian, Disking, Ron, Scheid, Johannes F., Gaebler, Christian, Mouquet, Hugo, Georgiev, Ivelin, Pancera, Marie, Zhou, Tongqing, Incesu, Reha-Baris, Fu, Brooks Zhongzheng, Gnanapragasam, Priyanthi N. P., Oliveira, Thiago Y., Seaman, Michael S., Kwong, Peter D., Bjorkman, Pamela J., Nussenzweig, Michel C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3792590/
https://ncbi.nlm.nih.gov/pubmed/23540694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.03.018
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados