HIV therapy by a combination of broadly neutralizing antibodies in humanized mice

Human antibodies to HIV-1 can neutralize a broad range of viral isolates in vitro and protect non-human primates against infection(1,2). Previous work showed that antibodies exert selective pressure on the virus but escape variants emerge within a short period of time(3,4). However, these experiment...

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Main Authors: Klein, Florian, Halper-Stromberg, Ariel, Horwitz, Joshua A., Gruell, Henning, Scheid, Johannes F., Bournazos, Stylianos, Mouquet, Hugo, Spatz, Linda A., Diskin, Ron, Abadir, Alexander, Zang, Trinity, Dorner, Marcus, Billerbeck, Eva, Labitt, Rachael N., Gaebler, Christian, Marcovecchio, Paola, Incesu, Reha-Baris, Eisenreich, Thomas R., Bieniasz, Paul D., Seaman, Michael S., Bjorkman, Pamela J., Ravetch, Jeffrey V., Ploss, Alexander, Nussenzweig, Michel C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3809838/
https://ncbi.nlm.nih.gov/pubmed/23103874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11604
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