Mammalian RAP1 controls telomere function and gene expression through binding to telomeric and extra-telomeric sites

Shelterin binds and protects mammalian telomeres. Here, we generated cells and mice conditionally deleted for the shelterin component RAP1. We find that Rap1 deficiency is dispensable for telomere capping but leads to increased telomere recombination and fragility. Mice with Rap1 deletion in stratif...

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Hauptverfasser: Martinez, Paula, Thanasoula, Maria, Carlos, Ana R., Gómez, Gonzalo, Tejera, Agueda M., Schoeftner, Stefan, Dominguez, Orlando, Pisano, David G., Tarsounas, Madalena, Blasco, Maria A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3792482/
https://ncbi.nlm.nih.gov/pubmed/20622869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2081
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