Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567

BACKGROUND AND PURPOSE: An increasing body of evidence suggests that the purinergic receptor P2X, ligand-gated ion channel, 7 (P2X7) in the CNS may play a key role in neuropsychiatry, neurodegeneration and chronic pain. In this study, we characterized JNJ-47965567, a centrally permeable, high-affini...

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Bibliografiska uppgifter
Huvudupphovsmän: Bhattacharya, Anindya, Wang, Qi, Ao, Hong, Shoblock, James R, Lord, Brian, Aluisio, Leah, Fraser, Ian, Nepomuceno, Diane, Neff, Robert A, Welty, Natalie, Lovenberg, Timothy W, Bonaventure, Pascal, Wickenden, Alan D, Letavic, Michael A
Materialtyp: Artigo
Språk:Inglês
Publicerad: Blackwell Publishing Ltd 2013
Ämnen:
Research Papers
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3792000/
https://ncbi.nlm.nih.gov/pubmed/23889535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12314
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