INTROGRESSION OF BROWN NORWAY CYP4A GENES ONTO THE DAHL SALT-SENSITIVE BACKGROUND RESTORES VASCULAR FUNCTION IN SS-5(BN) CONSOMIC RATS

This study tested the hypothesis that the Dahl salt-sensitive (SS) rat has vascular dysfunction due, in part, to the upregulation of the cytochrome P450-4A ω-hydroxylase (CYP4A)/20-hydroxyeicosatetraenoic acid (20-HETE) system. To assess the role of vascular 20-HETE, SS were compared to SS-5(BN) con...

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Detalhes bibliográficos
Main Authors: Lukaszewicz, Kathleen M, Falck, John R, Manthati, Vijaya L., Lombard, Julian H
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3791890/
https://ncbi.nlm.nih.gov/pubmed/22938512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/CS20120232
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