Sphingosine Kinase 1 Deficiency Confers Protection against Hyperoxia-Induced Bronchopulmonary Dysplasia in a Murine Model: Role of S1P Signaling and Nox Proteins

Bronchopulmonary dysplasia of the premature newborn is characterized by lung injury, resulting in alveolar simplification and reduced pulmonary function. Exposure of neonatal mice to hyperoxia enhanced sphingosine-1-phosphate (S1P) levels in lung tissues; however, the role of increased S1P in the pa...

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Hlavní autoři: Harijith, Anantha, Pendyala, Srikanth, Reddy, Narsa M., Bai, Tao, Usatyuk, Peter V., Berdyshev, Evgeny, Gorshkova, Irina, Huang, Long Shuang, Mohan, Vijay, Garzon, Steve, Kanteti, Prasad, Reddy, Sekhar P., Raj, J. Usha, Natarajan, Viswanathan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2013
Témata:
Regular Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3791871/
https://ncbi.nlm.nih.gov/pubmed/23933064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.06.018
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