Sphingosine Kinase 1 Deficiency Confers Protection against Hyperoxia-Induced Bronchopulmonary Dysplasia in a Murine Model: Role of S1P Signaling and Nox Proteins

Bronchopulmonary dysplasia of the premature newborn is characterized by lung injury, resulting in alveolar simplification and reduced pulmonary function. Exposure of neonatal mice to hyperoxia enhanced sphingosine-1-phosphate (S1P) levels in lung tissues; however, the role of increased S1P in the pa...

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Main Authors: Harijith, Anantha, Pendyala, Srikanth, Reddy, Narsa M., Bai, Tao, Usatyuk, Peter V., Berdyshev, Evgeny, Gorshkova, Irina, Huang, Long Shuang, Mohan, Vijay, Garzon, Steve, Kanteti, Prasad, Reddy, Sekhar P., Raj, J. Usha, Natarajan, Viswanathan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2013
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3791871/
https://ncbi.nlm.nih.gov/pubmed/23933064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.06.018
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