Intravaginal ring eluting tenofovir disoproxil fumarate completely protects macaques from multiple vaginal simian-HIV challenges

Topical preexposure prophylaxis interrupts HIV transmission at the site of mucosal exposure. Intermittently dosed vaginal gels containing the HIV-1 reverse transcriptase inhibitor tenofovir protected pigtailed macaques depending on the timing of viral challenge relative to gel application. However,...

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Autori principali: Smith, James M., Rastogi, Rachna, Teller, Ryan S., Srinivasan, Priya, Mesquita, Pedro M. M., Nagaraja, Umadevi, McNicholl, Janet M., Hendry, R. Michael, Dinh, Chuong T., Martin, Amy, Herold, Betsy C., Kiser, Patrick F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3791780/
https://ncbi.nlm.nih.gov/pubmed/24043812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1311355110
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