Intravaginal ring eluting tenofovir disoproxil fumarate completely protects macaques from multiple vaginal simian-HIV challenges

Topical preexposure prophylaxis interrupts HIV transmission at the site of mucosal exposure. Intermittently dosed vaginal gels containing the HIV-1 reverse transcriptase inhibitor tenofovir protected pigtailed macaques depending on the timing of viral challenge relative to gel application. However,...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Smith, James M., Rastogi, Rachna, Teller, Ryan S., Srinivasan, Priya, Mesquita, Pedro M. M., Nagaraja, Umadevi, McNicholl, Janet M., Hendry, R. Michael, Dinh, Chuong T., Martin, Amy, Herold, Betsy C., Kiser, Patrick F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2013
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3791780/
https://ncbi.nlm.nih.gov/pubmed/24043812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1311355110
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