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Ansamitocin P3 Depolymerizes Microtubules and Induces Apoptosis by Binding to Tubulin at the Vinblastine Site

Maytansinoid conjugates are currently under different phases of clinical trials and have been showing promising activity for various types of cancers. In this study, we have elucidated the mechanism of action of ansamitocin P3, a structural analogue of maytansine for its anticancer activity. Ansamit...

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Bibliografiske detaljer
Main Authors: Venghateri, Jubina B., Gupta, Tilak Kumar, Verma, Paul J., Kunwar, Ambarish, Panda, Dulal
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790769/
https://ncbi.nlm.nih.gov/pubmed/24124473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075182
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