Ansamitocin P3 Depolymerizes Microtubules and Induces Apoptosis by Binding to Tubulin at the Vinblastine Site

Maytansinoid conjugates are currently under different phases of clinical trials and have been showing promising activity for various types of cancers. In this study, we have elucidated the mechanism of action of ansamitocin P3, a structural analogue of maytansine for its anticancer activity. Ansamit...

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Hlavní autoři: Venghateri, Jubina B., Gupta, Tilak Kumar, Verma, Paul J., Kunwar, Ambarish, Panda, Dulal
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790769/
https://ncbi.nlm.nih.gov/pubmed/24124473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075182
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