Structure analysis of FAAP24 reveals single-stranded DNA-binding activity and domain functions in DNA damage response

The FANCM/FAAP24 heterodimer has distinct functions in protecting cells from complex DNA lesions such as interstrand crosslinks. These functions rely on the biochemical activity of FANCM/FAAP24 to recognize and bind to damaged DNA or stalled replication forks. However, the DNA-binding activity of th...

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Autori principali: Wang, Yucai, Han, Xiao, Wu, Fangming, Leung, Justin W, Lowery, Megan G, Do, Huong, Chen, Junjie, Shi, Chaowei, Tian, Changlin, Li, Lei, Gong, Weimin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790240/
https://ncbi.nlm.nih.gov/pubmed/23999858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2013.124
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