The N-degradome of Escherichia coli: LIMITED PROTEOLYSIS IN VIVO GENERATES A LARGE POOL OF PROTEINS BEARING N-DEGRONS

The N-end rule is a conserved mechanism found in Gram-negative bacteria and eukaryotes for marking proteins to be degraded by ATP-dependent proteases. Specific N-terminal amino acids (N-degrons) are sufficient to target a protein to the degradation machinery. In Escherichia coli, the adaptor ClpS bi...

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Detalhes bibliográficos
Main Authors: Humbard, Matthew A., Surkov, Serhiy, De Donatis, Gian Marco, Jenkins, Lisa M., Maurizi, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789986/
https://ncbi.nlm.nih.gov/pubmed/23960079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.492108
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