Mechanism for Recognition of an Unusual Mycobacterial Glycolipid by the Macrophage Receptor Mincle

Binding of the macrophage lectin mincle to trehalose dimycolate, a key glycolipid virulence factor on the surface of Mycobacterium tuberculosis and Mycobacterium bovis, initiates responses that can lead both to toxicity and to protection of these pathogens from destruction. Crystallographic structur...

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Main Authors: Feinberg, Hadar, Jégouzo, Sabine A. F., Rowntree, Thomas J. W., Guan, Yue, Brash, Matthew A., Taylor, Maureen E., Weis, William I., Drickamer, Kurt
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Glycobiology and Extracellular Matrices
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789947/
https://ncbi.nlm.nih.gov/pubmed/23960080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.497149
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